Fat Jabs

[Sandra]

It is the biggest shake-up of obesity treatment in history, it has been claimed.

From today, GPs will be able to prescribe weight-loss jabs to thousands.

[Sandra]

Fewer than one in 10 people who could benefit from obesity jabs like Wegovy are able to get them, warns the World Health Organization as it releases its first guidance on the drugs.

With more than one billion people worldwide now obese, it is calling for more widespread and fairer access to GLP-1 medication.

According to projections, more than two billion will be obese by 2030 unless action is taken.

High costs, limited production capacity, and supply-chain constraints are major barriers to universal access to the injections that can help people shift significant weight, says WHO.

It has already added them to its "essential" medicines list (for overweight patients with diabetes) that countries are advised to provide.

WHO director-general Tedros Adhanom Ghebreyesus said: "Our new guidance recognises that obesity is a chronic disease that can be treated with comprehensive and lifelong care.

"While medication alone won't solve this global health crisis, GLP-1 therapies can help millions overcome obesity and reduce its associated harms."

WHO says these drugs, sometime called skinny jabs, represent a new chapter in the gradual conceptual shift in how society approaches obesity, from a "lifestyle condition" to a complex, preventable, and treatable chronic disease.

It says the drugs can be taken long-term - for six months or more - but must be prescribed along with advice on diet and exercise, so that people can keep the weight off.

Too few people around the world can access them, says WHO. "Our greatest concern is equitable access," said Tedros.



Even under the current best projected scenario, the production of GLP-1 therapies could only cover around 100 million people - less than 10% of those who need them, according to the WHO.

The guideline calls on countries and companies to expand access, through strategies such as voluntary licensing - where a pharmaceutical company grants permission for others to make affordable non-brand versions of its patented drug.

A patent on semaglutide - the core ingredient of Novo Nordisk's Wegovy - is due to expire in several countries in 2026, meaning other drug-makers will soon be free to produce and sell cheap versions in places like India, Canada, China, Brazil and Turkey.

WHO says countries must also create healthier environments to promote good health and prevent obesity.
How obesity jabs work

GLP-1 drugs mimick a natural hormone to slow digestion, curb appetite and increase feelings of fullness so people eat less.

In the UK, the injections are prescription only medicines, which means they can only be prescribed by a healthcare professional for a person who clinically needs it.

Some are available on the NHS, but more are sold privately.

There is a black market and to be safe people should avoid buying from unregulated sellers such as beauty salons or via social media.

People typically start to lose weight within a few weeks of starting on the weekly injections.

Research suggests people may put most of the weight back on within a year of stopping the medication though, as their normal food cravings return.

Being overweight or obese increases your risk for developing health problems, such as diabetes, heart disease, stroke, and certain cancers.

Obesity affects people in every country and was associated with 3.7 million deaths worldwide in 2024, according to the WHO.

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[Sandra]

How Weight-Loss Jabs Work

Appetite suppression:

They mimic a natural gut hormone called GLP-1 (glucagon-like peptide-1), which signals your brain that you are full.

Slower digestion:

They slow down how fast food leaves your stomach so you feel full for a longer time.

Metabolism support:

Newer drugs like Mounjaro also mimic a second hormone called GIP to help regulate energy balance and blood sugar.

How Much Weight Do People Lose?

Mounjaro (tirzepatide):

Clinical trials show an average weight reduction of about 20% over 72 weeks.

Wegovy (semaglutide):

Clinical trials show an average weight reduction of about 14% over a similar period.

Results timeline:

People typically start noticing reduced hunger within days and visible weight loss within a few weeks.

Side Effects and Risks Common issues:

Users often experience nausea, vomiting, diarrhea, constipation, and stomach pain.

Muscle loss:

Rapid weight loss can cause the body to lose muscle mass as well as fat, making exercise and protein intake important.

Serious risks:

Rare complications can include gallbladder disease or inflammation of the pancreas.

The Challenge of Stopping Weight regain:

Studies show that many people quickly put the weight back on once they stop taking the injections because their normal food cravings return.

Long-term commitment:

Experts and organizations like the British Heart Foundation note that these treatments often need to be continued long-term, alongside healthy habits, to maintain the weight loss.

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